OTC Drugs Acetaminophen (Tylenol), ibuprofen (Advil), and naproxen (Aleve)
How effective are they? All ease body aches and reduce fever.
What are the risks? Acetaminophen is safe when used as directed, but even taking a little more than the daily max can harm the liver. The other drugs-nonsteroidal and anti-inflammatories, or NSAIDs-can cause intestinal bleeding and increase the risk of heart attack and kidney damage.
What they can interact with: Acetaminophen plus alcohol can threaten the liver. NSAIDs increase the risk of bleeding when taken with a blood thinner such as warfarin (Coumadin) or clopidogrel (Plavix).
Source: Consumer Reports magazine January 2018
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