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Latest from the NCI

  • Changes in Metabolism Help Melanomas Spread
    Melanoma cells that metastasize to other parts of the body produce high levels of a protein called MCT1, a new study in mice has found. Blocking MCT1 with an investigational drug, AZD3965, led to fewer and smaller metastatic tumors. Read more »
  • Maintenance Therapy with CC-486 Extends Survival of Adults with AML
    Maintenance therapy with CC-486 extended overall survival of adults with the blood cancer acute myeloid leukemia (AML) in a large clinical trial. CC-486 is a pill form of another cancer therapy called azacitidine (Vidaza). Read more »
  • Enfortumab Vedotin Approved for Recurrent Bladder Cancer
    Enfortumab vedotin-ejfv (Padcev) has been approved for people with advanced bladder cancer. FDA granted the drug accelerated approval for cancers that have progressed despite previous treatments. Read more »
  • For Metastatic HER2-Positive Breast Cancer, New Treatments Emerge
    Tucatinib improved survival for women in the HER2CLIMB trial, including some whose cancer had spread to the brain. Trastuzumab deruxtecan improved survival and shrank many tumors in the DESTINY-Breast01 trial, which led to its accelerated approval. Read more »
  • Brain Cancer Cells Hijack Gene “On Switches” to Drive Tumor Growth
    Glioblastoma cells sneak many copies of a key oncogene into circular pieces of DNA. In a new NCI-funded study, scientists found that the cells also slip several different genetic “on switches” into these DNA circles, helping to fuel the cancer’s growth. Read more »
  • New on NCI’s Websites for January 2020
    NCI periodically provides updates on new websites and other online content of interest to the cancer community. See selected content that has been added as of January 2020. Read more »
  • Oncofertility: Creating a Bridge Between Cancer Care and Reproductive Health
    Dr. Teresa Woodruff discusses the field that connects oncology with reproductive health, and the Oncofertility Consortium’s efforts to support clinicians, cancer patients, and families in understanding how cancer and its treatment affect fertility. Read more »
  • Anal Cancer Incidence and Deaths Are Rising in the United States
    The number of cases and deaths from anal cancer have been on the rise in the United States since 2001, according to a new study. The increases have been especially rapid in two segments of the population. Read more »


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