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The fusion protein that drives the growth and survival of some rhabdomyosarcoma tumors relies on the KDM4B enzyme, researchers have found. Treating mice with a KDM4B-blocking drug and chemotherapy nearly eliminated rhabdomyosarcoma tumors with the fusion protein. Read more » - Aided by Community Health Workers, People with Advanced Cancer Need Fewer Hospital Visits
Regular visits and calls from community health workers showed many benefits for those with advanced cancers, from greater use of palliative care to improved quality of life, a new study has shown. Read more » - New Cancer Model Shows Promise in Predicting If Treatment Will Shrink Tumors
A research team hopes to offer oncologists a new tool to guide treatment choices for their patients. In a small study, a tumor model called micro-organospheres accurately predicted whether patients would respond to their chemotherapy treatment. Read more » - Disguising Cancer as an Infection Helps the Immune System Eliminate Tumors
NCI researchers are developing an immunotherapy that involves injecting protein bits from cytomegalovirus (CMV) into tumors. The proteins coat the tumor, causing immune cells to attack. In mice, the treatment shrank tumors and kept them from returning. Read more » - Dabrafenib–Trametinib Combination Approved for Solid Tumors with BRAF Mutations
FDA has approved the combination of the targeted drugs dabrafenib (Tafinlar) and trametinib (Mekinist) for nearly any type of advanced solid tumor with a specific mutation in the BRAF gene. Data from the NCI-MATCH clinic trial informed the approval. Read more » - Androgen Receptor May Explain Sex Differences in Melanoma Treatment Response
Male patients with metastatic melanoma don’t live as long as females, and their tumors are more likely to become resistant to commonly used treatments. A new study may help explain why: the androgen receptor. Read more » - Immunotherapy’s Skin Side Effects: Are Microbes to Blame?
People with cancer who take immunotherapy drugs often develop skin side effects, including itching and painful rashes. New research in mice suggests these side effects may be caused by the immune system attacking new bacterial colonies on the skin. Read more » - Ifosfamide May Be Treatment of Choice for Some People with Ewing Sarcoma, Trial Shows
New findings from the first large, randomized clinical trial to compare chemotherapy regimens for relapsed or treatment-resistant Ewing sarcoma could help doctors and patients select treatments. Read more »