Radiation therapy has a major role in the palliation of localized symptomatic metastases, Indications for external-beam radiation therapy include the following: Painful bony metastases. Unresectable central nervous system metastases (i.e., brain, meninges, and spinal cord). Bronchial obstruction. Fungating/painful breast or chest wall lesions. After surgery for decompression of intracranial or spinal cord metastases. After fixation of pathologic fractures. Strontium chloride Sr 89, a systemically administered radionuclide, can be administered for palliation of diffuse bony metastases.
Source: NCI 2019