When pain is mild to moderate, the first choice for pain relief is usually a non-opioid drug. Examples of these drugs include ibuprofen (such as Advil or Motrin), naproxen (Aleve or Naprosyn) and acetaminophen (Tylenol). Although you can get these medications without a prescription, check with your health care provider before taking them. There may be medical reasons you shouldn’t take these drugs. If pain persists or becomes worse, opioid drugs in combination with or instead of non-opioid drugs give added pain relief. In general, the more pain medication you take, the more side effects you will have. Health care providers try to treat pain with the least amount of medication to limit side effects.
Source: Susan G. Komen 2019